MOLEKULARNA CHARAKTERYSTYKA
CZYNNIKÓW WIRULENCJI
ACTINOBACILLUS ACTINOMYCETEMCOMITANS
Katarzyna Affek, Elżbieta Katarzyna Jagusztyn-Krynicka
Zakład Genetyki Bakterii, Instytut Mikrobiologii Uniwersytetu Warszawskiego,
02-096 Warszawa, ul. Miecznikowa 1,
e-mail: kjkryn@biol.uw.edu.pl
Wpłynęło w grudniu 2006 r.
1. Choroby zakaźne jamy ustnej. 1.1 Paradontoza. 2. Actinobacillus actinomycetemcomitans - charakterystyka
patogenu. 2.1 Genom. 3. Czynniki wirulencji. 3.1 Adhezyny. 3.2 Inwazyjność. 3.3. Toksyny. 3.3.1 Leukotoksyna. 3.3.2 Toksyna
CDT. 3.4 Białko GroEL. 4. Podsumowanie.
Molecular characteristics of Actinobacillus actinomycetemcomitans virulence factors
Abstract: Periodontal diseases are a group of chronic inflammatory diseases of the gingiva and the supporting structure of the periodontium that lead to the destruction of the tooth supporting tissues, i.e. the periodontal ligament, the gingival connecting tissue, and the alveolar bones.
Actinobacillus actinomycetemcomitans has been implicated, as a causative agent of localized aggressive periodontitis, in severe and rapid form of periodontal disease. The pathogenicity of
A. actinomycetemcomitans is multi-faceted and the pathophysiology of the infection is influenced by both microbial and host determinants. The bacterium has been found to be capable of binding to and invading epithelial and endothelial cells. The process is an important mechanism for evading host defenses and spreading beyond the initial site of infection.
A. actinomycetemcomitans expresses a number of virulence factors including many adhesins, two toxins (leukotoxin RTX, CDT toxin) and chaperonin 60, which allows the bacterium to form extremely tena-cious biofilm and to interact with the immune system. This review describes recent findings concerning the molecular aspects of
A. actinomycetemcomitans pathogenesis.
1. Infectious diseases of the oral cavity. 1.1 Periodontitis. 2. Actinobacillus actinomycetemcomitans - pathogen characterization. 2.1 Genome. 3. Virulence factors. 3.1 Adhesins. 3.2 Invasion. 3.3 Toxins. 3.3.1 Leukotoxin. 3.3.2 CDT toxin. 3.4 GroEL protein. 4. Summary
Słowa kluczowe: Actinobacillus actinomycetemcomitans, CDT,
LAP,
leukotoksyna, paradontoza
Key words: Actinobacillus actinomycetemcomitans, CDT, LAP,
leukotoxin,
periodontitis
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