TAJEMNICA CHOROBOTWÓRCZOŚCI
VIBRIO CHOLERAE PRZECINKOWCA CHOLERY
W STO LAT PO ŚMIERCI ROBERTA KOCHA
Skrót wykładu przedstawionego na Konferencji naukowej „Mikrobiologia 100 lat po Robercie Kochu " Polskiego Towarzystwa Mikrobiologów w Warszawie w dniach 30—31sierpnia 2010 r.
Hanna Stypulkowska-Misiurewicz*
Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny,
ul. Chocimska 24, 00-791 Warszawa
Wpłynęło w 2010 r.
1. Wprowadzenie. 2. V. cholerae gatunkiem chorobotwórczym. 3. Toksyny V. cholerae. 4. V. cholerae non-O1. 5. Pochodzenie epidemicznych szczepów V. cholerae. 6. Podsumowanie
The mystery of Vibrio cholerae pathogenic activity a hundred years after the Robert Koch's death
Abstract: In his rapport from Calcutta published in 1884 in German press of Berlin Robert Koch described Vibrio as an etiological agent of cholera, in spite that the germ did not caused cholera symptoms in the animals infected in laboratory [9]. The research works connected with VII pandemic of cholera that started in 1961 solved the problem by the demonstration of the toxic activity of the V. cholerae on biological models. New important information concerning the bacteriological media for isolation of cholera vibrio, vibrio genetics, cholera toxins, vibrio virulence and survival of cholera vibrio in the environment brought new solutions for surveillance, prevention and control of cholera in the world. The epidemic outbreaks of cholera in some European countries, in Slovakia and Ukraine in 1970 caused the conditions that a group of workers of National Institute of Hygiene in Warsaw started to work on microbiological methods for examination for V. cholera the patients and healthy contacts, water and food, as well as to instruct the sanitary stations staff for epidemiological and laboratory investigation. The cooperation with researchers in Europe and other countries were developed to exchange the most important news. The pandemic of cholera faded but still remained several unsolved problems that actually are investigated by researchers in countries developed as well as underdeveloped working together as cholera remain a heavy burden to many poor regions in the world.
1. Introduction. 2. V. cholerae the pathogenic genus. 3. The V. cholerae toxins. 4. V. cholerae non-O1 strains. 5. Origin of V. cholera epidemic strains. 6. Summary
Słowa kluczowe: Przecinkowce, Vibrio cholerae, pandemie cholery, toksyny choleryczne
Key words: Vibrio, V. cholerae, cholera pandemics, cholera toxins
|
