BARTONELLA SP. - MECHANIZM INDUKOWANEJ
PRZEZ BAKTERIE ANGIOGENEZY
Anna Maria Stachowicz1 i Elżbieta Katarzyna Jagusztyn-Krynicka1*
1Zakład Genetyki Bakterii, Instytut Mikrobiologii Uniwersytetu Warszawskiego, 02-096 Warszawa, ul. Miecznikowa 1
Wpłynęło w lutym 2010 r.
1. Wstęp. 2. Interakcje Bartonella spp. z komórkami eukariotycznymi. 3. Patogeneza, czynniki wirulencji. 4. Inhibicja apoptozy. 5. NFkB - główny regulator reakcji zapalnej. 6. Parakrynna pętla proliferacji komórek śródbłonka naczyń. 7. Podsumowanie
Bartonella sp.- mechanism of bacteria-induced angiogenesis
Abstract: The alpha-proteobacterial genus Bartonella comprises numerous pathogens causing characteristic intraerythrocytic bacteremia in their reservoir hosts. Since 1993 the genus Bartonella expanded from one species to currently 24 species, more than ten of which are associated with human diseases. Some members of Bartonella genus are recognized as zoonotic pathogens. Transmission between mammalian host occurs via blood sucking arthropods or via direct contact. Three species (B. bacilliformis, B. quintana and B. henslae) are the most important human pathogens that cause a wide spectrum of clinical manifestations such as: cat-scratch disease (CSD), trench fever, Carrion's disease, bacillary angiomatis (BA) and peliosis (BP). In humans Bartonellae infect erythrocytes and vascular endothelial cells (EC). Invasion of EC can lead to vasoproliferative tumour lesions in the skin and inner organs. This review paper provides an overview of Bartonella - host cell interaction concentrating on vascular tumor proliferation.
1. Introduction. 2. Bartonella - host cell interactions. 3. Pathogenesis, virulence factors 4. Inhibition of apoptosis. 5. NFkB - main factor of proinflamatory reaction. 6. Paracrine loop of endothelial cell proliferation. 7. Summary
Słowa kluczowe: Bartonella spp.; proliferacja komórek śródbłonka, wewnątrzerytrocytarna bakteriemia, VEFG, T4SS (czwarty typ sekrecji)
Key words: Bartonella spp.; vascular proliferation, intraerythrocytic bacteremia, VEGF, T4SS (type four secretion system)
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