NOWE SZCZEPIONKI PRZECIW HERPESWIRUSOM
I WEKTORY HERPESWIRUSOWE W TERAPII CZŁOWIEKA
Wykład przedstawiony na Konferencji naukowej
„Mikrobiologia 100 lat po Robercie Kochu"
Polskiego Towarzystwa Mikrobiologów
w Warszawie w dniach 30—31 sierpnia 2010 r.
Andrea Lipińska1*, Krystyna Bieńkowska-Szewczyk1
1Katedra Wirusologii Molekularnej, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
1. Wstęp. 2. Szczepionki przeciw wirusowi ospy wietrznej i półpaśca. 3. Badania nad szczepionkami przeciw wirusom HSV, ludzkiemu cytomegalowirusowi i wirusowi Epsteina-Barr. 4. Wektory herpeswirusowe w terapii człowieka. 5. Podsumowanie
Novel antiherpesviral vaccines and herpesviral vectors for human therapy
Abstract: Herpesviruses constitute one of the largest viral families, which encompasses viral infectious agents widely occurring in the human population. The use of antiviral therapeutics usually does not prevent herpesvirus recurrences and has not lead to the virus eradication. This may be achieved with antiviral vaccines. Despite a long track of vaccine clinical trials and numerous strategies of research, commercial vaccines are available only for one herpesvirus - varicella-zoster virus (VZV). In addition to the varicella vaccine, a therapeutic vaccine to prevent herpes zoster in elderly people has been recently introduced. This paper reviews the most recent developments in human herpesvirus vaccines, both prophylactic and therapeutic. The most promising clinical trials, which may lead to successful vaccines in the near future, are described. The most important challenges for the vaccine research are also discussed. The therapeutic use of herpesviruses includes recombinant HSV vectors for gene delivery or as anti-cancer agents. HSV therapeutic vectors are classified into: amplicon vectors, replication-defective vectors and replication-attenuated oncolytic viruses. This paper gives an insight into the current knowledge on the construction of HSV vectors for human therapy and describes the most recent advances in the oncolytic virotherapy.
1. Introduction. 2. Varicella-zoster virus vaccines. 3. Development of HSV, human cytomegalovirus and Epstein-Barr virus vaccines. 4. Herpesviral vectors for human therapy. 5. Summary
Słowa kluczowe: herpeswirusy, szczepionki, terapia onkolityczna
Key words: herpesviruses, vaccines, oncolytic therapy
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