UDZIAŁ TOLL-LIKE RECEPTORÓW
W ZAKAŻENIACH GRZYBICZYCH
Dorota Plewik*, Maria Koziol-Montewka
Katedra i Zakład Mikrobiologii Lekarskiej Uniwersytetu Medycznego w Lublinie
ul. Chodki 1, 20-059 Lublin
Wpłynęło w marcu 2010 r.
1. Wstęp. 2. Budowa i szlak aktywacji. 3. Funkcja TLR. 4. TLR w zakażeniach grzybiczych. 5. Polimorfizm genów TLR. 6. Wnioski
Toll-like receptor participation in fungal infections
Abstract: Immune system dysfunction is the major risk factor for developing invasive fungal infection. Toll Like Receptors (TLR) are present on cells of the immune system as well as on other cells localized at sites that can potentially be portals of entry for pathogens. TLRs recognize a number of fungal structures and play an important role in the immune response against fungal pathogens. The receptor-ligand binding triggers protein cascade, translocation of NF-kB into the cell nucleus and activation of target genes. Receptors' activation induces the production of some proinflammatory factors, and the activation of innate and adaptive immune responses. Among the discovered 13 different TLRs, fungal ligands are specifically recognized by TLR2, 4 and 9. Scientific research of the recent years confirm the relationship between TLR gene polymorphism in humans and susceptibility to invasive fungal infections.
1. Introduction. 2. Structure and activation pathway. 3. Function of TLRs. 4. TLR in fungal infections. 5. Polymorphisms in TLR genes. 6. Conclusions
Słowa kluczowe: grzyby, polimorfizm genów, receptory Toll-like
Key words: fungus, genes polymorphism, Toll-like receptors
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