BAKTERIOCYNY PROBIOTYCZNYCH PAŁECZEK
Z RODZAJU LACTOBACILLUS
Anna Słońska*, Danuta Klimuszko
Zakład Bakteriologii i Biologii Molekularnej,
Katedra Nauk Przedklinicznych Wydział Medycyny Weterynaryjnej,
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie
Wpłynęło w marcu 2010 r.
1. Wprowadzenie. 2. Struktura genomu i plazmidy. 3. Bakteriocyny. 4. Klasyfikacja bakteriocyn. 5. Organizacja operonu biosyntezy bakteriocyn. 6. Lokalizacja operonu biosyntezy bakteriocyn. 7. Biosynteza bakteriocyn. 8. Mechanizm działania bakteriocyn. 9. Bakteriocynogenność a właściwości probiotyczne bakterii z rodzaju Lactobacillus. 10. Podsumowanie
Bacteriocins produced by probiotic rods of the genus Lactobacillus
Abstract: Lactobacillus is a genus of non-spore-forming, non-motile, Gram-positive facultative anaerobic or microaerophilic rods. They are important part of normal human and animal bacterial flora commonly associated with the gastrointestinal tract and genitourinary tract of animals and humans. They are able to produce antimicrobial substances such as bacteriocins, lactic acid and hydrogen peroxide, which have been shown to be beneficial for controlling the overgrowth of other, potentially pathogenic, bacteria. Bacteriocins are low-molecular weight single polypeptides or polypeptide complexes having an antimicrobial activity, synthesized in ribosome and secreted by bacterial cells. Genes encoding bacteriocins have been reported to be present on plasmid or genomic DNA. Lactobacilli are commonly used in the production of probiotics - a live microbial food supplements which beneficially affect the host by improving its intestinal microbial balance. They have found wide application in probiotic products which are used to balance disturbed intestinal microflora and related dysfunctions of the gastrointestinal track.
1. Introduction. 2. Genome structure and plasmids. 3. Bacteriocins. 4. Classification of bacteriocins. 5. Operon organization of bacteriocin genes. 6. Localization of the bacteriocin operons. 7. Biosynthesis of bacteriocins. 8. Mechanizm of action of bacteriocins. 9. Bacteriocinogenicity and probiotic properties of Lactobacillus sp. 12. Summary
Słowa kluczowe: bakteriocyny, Lactobacillus sp., właściwości probiotyczne
Key words: bacteriocins, Lactobacillus sp., probiotic properties
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