WPŁYW PAŁECZEK SHIGELLA SP.
NA ŚMIERĆ KOMÓRKI EUKARIOTYCZNEJ
Joanna Kwiecińska-Piróg1*, Małgorzata Prażyńska1, Adrian Reśliński1, 2, Eugenia Gospodarek1, Wojciech Szczęsny2, Stanisław Dąbrowiecki2
1Katedra i Zakład Mikrobiologii Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu
2Katedra i Klinika Chirurgii Ogólnej i Endokrynologicznej Collegium Medicum im. L. Rydygiera w Bydgoszczy
Uniwersytet Mikołaja Kopernika w Toruniu
Wpłynęło w lipcu 2008 r.
1. Wstęp. 2. Charakterystyka zakażenia Shigella sp. 3. Wpływ pałeczek Shigella sp. na śmierć komórki. 3.1. Działanie apoptotyczne. 3.2. Hamowanie apoptozy przez pałeczki Shigella sp. 3.3. Wpływ Shigella sp. na autofagię. 3.4. Wpływ pałeczek Shigella sp. na nieprogramowaną śmierć komórki. 3.4.1 Wpływ pałeczek Shigella sp. na onkozę. 3.4.2. Wpływ pałeczek Shigella sp. na nekrozę. 4. Podsumowanie
The effect of Shigella sp. rods on eukaryotic cell death
Abstract: Cell death plays an important role in the development and homeostasis of multicellular organisms. The identified mechanisms of cell death can be divided into two types: programmed and non-programmed. Programmed cell death includes apoptosis and autophagy. The second type is represented by necrosis and oncosis.
Apoptosis is a form of cell death under genetic control. Membrane blebbing, nuclear condensation and DNA fragmentation are characteristic features of apoptosis. During apoptosis there is an activation of caspases such as caspase-3. Autophagy is a normal physiological process involved in routine turnover of cell constituents. It is characterized by formation of many large autophagic vacuoles. Primary proteases are cathepsins or proteosomal proteins. Necrosis is a form of uncontrolled cell death. It is accompanied by loss of ATP and swelling of cell membrane and organelles. In contrast to apoptosis and autophagy, necrosis causes an inflammatory response. Oncosis can be defined as cell death accompanied by cellular swelling, organelle swelling, blebbing and increased membrane permeability. The mechanism of oncosis is based on disfunction of the ionic pumps of the plasma membrane. It is usually caused by ischemia and toxic agents that interfere with ATP generation.
Thereis much evidence that bacterial pathogens modulate host cell death pathways. One group of bacteria that can induce or inhibit cell death are Shigella sp. rods. These bacteria are etiological agents of bacterial dysentery. Research has demonstrated that modulation of the host cell death pathways is an integral part of pathogenesis of this disease.
The effect of Shigella sp. rods on the death of the of infected cells is not fully understood. Further studies are necessary to help prevent and treat bacterial dysentery.
1. Introduction. 2. Characteristics of Shigella sp. infection 3. Impact of Shigella sp. rods on cell death 3.1. Apoptotic action. 3.2. Inhibition of apoptosis by Shigella sp. rods. 3.3. Effect of Shigella sp. on autophagy. 3.4. Effect of Shigella sp. rods on non-programmed cell death. 3.4.1. Impact of Shigella sp. rods on oncosis. 3.4.2. Effect of Shigella sp. rods on necrosis. 4. Summary
Słowa kluczowe: śmierć komórki, apoptoza, pałeczki Shigella sp.
Key words: cell death, apoptosis, Shigella sp. rods
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