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METICYLINOOPORNE SZCZEPY
STAPHYLOCOCCUS INTERMEDIUS WYSTĘPUJĄCE U PSÓW
JAKO POTENCJALNY REZERWUAR GENU MECA
Dorota Chrobak, Magdalena Kizerwetter-Świda, Magdalena Rzewuska,
Marian Binek*
Zakład Bakteriologii i Biologii Molekularnej, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, 02-786 Warszawa, ul. Ciszewskiego 8
Wpłynęło w listopadzie 2009 r.
1. Wstęp. 2. Źródło i sposób powstawania szczepów meticylinoopornych. 3. Znaczenie kliniczne Staphylococcus intermedius. 4. Indukcja lekooporności Staphylococcus intermedius. 5. Przenoszenie się szczepów Staphylococcus intermedius między psami i ludźmi. 6. Występowanie genu mecA u Staphylococcus intermedius. 7. Podsumowanie
Pet-aquired methicillin-resistant Staphylococcus intermedius (PA-MRSI) as a potential reservoir for mecA gene
Abstract: Veterinary surveillance programs on the usage of antimicrobial agents and the occurrence of resistance in bacteria focus mainly on animal husbandry and generally do not provide data on companion animals. The increasing worldwide use of antimicrobial agents in small animal veterinary practice contributes to the spread of antimicrobial resistance. The close, sometimes physical, relationship between dogs and cats and human beings might present substantial risk that resistant bacteria or resistance genes could be transferred from pet animals to humans. The emergence and dissemination of antimicrobial resistance among staphylococci is an important problem in human and veterinary medicine. An alarmingly high frequency of methicillin resistance in clinically isolated Staphylococcus intermedius strains has been observed worldwide. Zoonotic transmission of both methicillin-susceptible and methicillin-resistant S. intermedius from dogs to humans is already well recognized. The genetic determination of methicillin resistance is mediated by vectors termed staphylococcal cassette chromosome which containe the mecA gene. The high prevalence of this resistance vector in companion animals can affect the horizontal transmission from dogs to humans, since the pet-acquired methicillin resistant S. intermedius may be a potential reservoir for these elements.
1. Introduction. 2. The origin and reservoirs of SCCmec. 3. Clinical significance of S. intermedius in human and veterinary medicine. 4. Induction of antimicrobial resistance in S. intermedius. 5. Zoonotic transmission of Staphylococcus intermedius from canine pets to humans. 6. mecA gene harboured by S. intermedius. 7. Summary
Słowa kluczowe: gen mecA, lekooporność, Staphylococcus intermedius, transmisja, zwierzęta
Key words: mecA gene, drug resistance, Staphylococcus intermedius, transmission, companion animals
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