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APOPTOZA U DROŻDŻY PĄCZKUJĄCYCH
SACCHAROMYCES CEREVISIAE
- MECHANIZM ŚMIERCI CZY PRZETRWANIA?
Małgorzata Szabelska, Eugenia Gospodarek*, Emilia Ciok-Pater
Katedra i Zakład Mikrobiologii, Collegium Medicum im. Ludwika Rydygiera
w Bydgoszczy UMK w Toruniu, 85-094 Bydgoszcz, ul. M. Skłodowskiej-Curie 9
Wpłynęło w marcu 2007 r.
1. Wstęp. 2. Drożdże Saccharomyces cerevisiae modelowym organizmem eukariotycznym. 3. Czynniki indukujące apoptozę u Saccharomyces cerevisiae. 4. Czynniki pro- i antyapoptotyczne w komórkach Saccharomyces cerevisiae. 5. Fizjologiczna rola programowanej śmierci komórkowej u Saccharomyces cerevisiae. 6. Podsumowanie
Apoptosis in the budding yeast Saccharomyces cerevisiae — mechanism of death or survival?
Abstract: Apoptosis is a highly regulated form of programmed cell death (PCD) crucial for life and health in Metazoa. Yeast have been used as a model eucaryotic organism to study apoptosis. Unexpectedly, several researchers observed a PCD process in yeast in response to heterologous expression of proapoptotic genes. Following that discovery, different factors inducing apoptosis in yeast cells were identified, e.g. H2O2, acetic acid, cellular ageing, failed mating. Further investigations revealed that several regulators of apoptosis are conserved between Metazoa and yeast. There are three natural conditions of yeast population i.e. environmental stress conditions, failure to mate, and aging in which PCD in yeast cells occurrs and seems to be beneficial for the whole population. Therefore, PCD might serve as an important regulator of yeast cell populations. However, the lack of homologs of crucial PCD regulators, such as Bcl-2 family proteins or unidentified genuine substrates for Yeast Caspase-1, make the existance of PCD mechanism in yeast disputable. The ability to manipulate fungi still presents exciting challenges. The manipulations of fungal PCD could provide a basis for future therapies.
1. Introduction. 2. The yeast Saccharomyces cerevisiae as a model eukaryotic organism. 3. Apoptosis inducing factors in Saccharomyces cerevisiae. 4. Pro- and antiapoptotic factors in Saccharomyces cerevisiae cells. 5. Physiological role of programmed cell death in Saccharomyces cerevisiae. 6. Conclusion
Słowa kluczowe: apoptoza, drożdże, kaspazy, PCD, ROS
Key words: apoptosis, yeast, caspases, PCD, ROS
* Autor korespondencyjny: Katedra i Zakład Mikrobiologii, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, UMK w Toruniu; 85-094 Bydgoszcz, ul. M. Skłodowskiej-Curie 9; tel. (052) 585-40-47; e-mail: kizmikrob@cm.umk.pl
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