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WŁAŚCIWOŚCI ANTYAPOPTOTYCZNE BAKTERII
Adrian Reśliński, Joanna Kwiecińska, Eugenia Gospodarek
Katedra i Zakład Mikrobiologii Collegium Medicum im. L. Rydygiera
w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu,
ul. M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz
tel. (52) 585 40 470, e-mail: kizmikrob@cm.umk.pl
Wpłynęło w listopadzie 2007
1. Wstęp. 2. Przebieg apoptozy. 3. Hamowanie apoptozy przez bakterie. 3.1. Bezpośrednie oddziaływanie z elementami szlaku apoptozy. 3.2.1. Udział czynnika transkrypcyjnego NF-kB. 3.2.2. Udział szlaku PI3K/Akt. 4. Podsumowanie
Bacterial antiapoptotic properties
Abstract: Apoptosis or programmed cell death is an active, genetically controlled process. It is an integral part of life that maintains homeostasis in multicellular organisms. In contrast to necrosis, apoptosis allows the organism to eliminate unnecessary or damaged cells without an inflammatory reaction.
Programmed cell death also plays an important role in the pathogenesis of various infectious diseases. There is much evidence, that bacteria have the ability to induce and/or block apoptosis. Bacteria can inhibit programmed cell death in a direct or indirect way. In the first case, bacteria directly interact with the apoptotic pathway. Indirect effect on apoptosis is mediated through signal transduction pathways inside the host cell such as the nuclear factor kappa B (NF-kB) and phosphatidylinositol-3-kinase/Akt (PI3K/Akt) pathways.
Many mechanisms by which bacterial pathogens inhibit the host cell apoptotic pathways are not fully understood. Further studies are necessary for a better understanding of the host-pathogen relationship.
1. Introduction. 2. Course of apoptosis. 3. Inhibition of apoptosis by bacteria. 3.1. Direct interaction with the elements of an apoptotic pathway. 3.2.1. Contribution of nuclear factor NF-kB. 3.2.2. Contribution of PI3K/Akt pathway. 4. Summary
Słowa kluczowe: apoptoza, czynnik jaądrowy NF-kB, szlak PI3K/Akt
Key words: apoptosis, nuclear factor NF-kB, PI3K/Akt pathway
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