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GORĄCZKA KRWOTOCZNA EBOLA.
IMMUNOLOGICZNE I MOLEKULARNE
MECHANIZMY PATOGENEZY, DIAGNOSTYKA,
EKSPERYMENTALNE METODY LECZENIA I UODPARNIANIA
Maciej Łuczkiewicz1, Magdalena Joanna Flaga2
1Zakład Wirusologii, Instytut Mikrobiologii, Wydział
Biologii UW,
ul. Miecznikowa l, 02-096 Warszawa, tel. (022) 5541421, e-mail:
maciej@biol.uw.edu.pl
2Akademia Medyczna w Warszawie, I Wydział Lekarski,
ul. Żwirki i Wigury 61, 02-091 Warszawa
Wpłynęło w listopadzie 2006 r.
1. Historia odkrycia wirusa. Epidemie gorączki
krwotocznej Ebola. 2. Obraz kliniczny gorączki krwotocznej Ebola.
3. Przebieg infekcji. 4. Budowa i funkcje białek wirusa.
5. Diagnostyka gorączki krwotocznej Ebola. 6. Leczenie.
7. Eksperymentalne metody uodparniania czynnego. 8. Podsumowanie
Ebola haemorrhagic fever. Immunological and molecular mechanisms
of pathogenesis, diagnostics, experimental methods of therapy
and vaccination
Abstract: Two outbreaks of unknown haemorrhagic fever occured
in 1976 in central Africa. Mortality rate was very high, reaching
90%. Isolated virus was classified as a new member of the
Filoviridae family and called Ebola. In the following years several
new outbreaks occured. The possibility of occurrence of this disease
in developed countries and the threat of bioterrorism motivate many
scientific centers to carry on the research on the mechanisms
of pathogenesis trying to find effective treatment and vaccines.
Experimental models using Ebola virus proteins (which do not require
biosafety level (4 laboratories) have simplified investigations o f
viral protein functions. This review presents up-to-date knowledge
about mechanisms of pathogenesis, molecular structure and function
of viral proteins, rapid detection of Ebola hemorrhagic fever cases
and experimental treatment as well as vaccination against this
extremely dangerous disease.
1. Discovery of Ebola virus. Known Ebola haemorrhagic fever
outbreaks. 2. Clinical symptoms of Ebola haemorrhagic fever.
3. Course of infection. 4. Structure and functions of viral
proteins. 5. Diagnostics of Ebola haemorrhagic fever. 6. Treatment.
7. Experimental vaccines. 8. Summary
Słowa kluczowe: Ebola, Filoviridae, glikoproteina, krwotoki,
Marburg
Key words: Ebola, Filoviridae, glycoprotein, haemorrhage,
Marburg
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