POST. MIKROBIOL.,
2007, 46, 2, 101-112
http://www.pm.microbiology.pl

 

CORYNEBACTERIUM PSEUDOTUBERCULOSIS
- ZAKAŻENIA U ZWIERZĄT

Ilona Stefańska, Magdalena Rzewuska, Marian Binek
Zakład Bakteriologii i Biologii Molekularnej, Katedra Nauk Przedklinicznych,
Wydział Medycyny Weterynaryjnej SGGW,
ul. Ciszewskiego 8, 02-786, Warszawa,
e-mail: binek@alpha.sggw.waw.pl

Wpłynęło w lutym 2006 r.

1. Wstęp. 2. Budowa ściany koórkowej Corynebacterium sp. 3. Właściwości C. pseudotuberculosis. 4. Biotypy C. pseudotuberculosis. 5. Występowanie. 6. Chorobotwórczość. 7. Patomechanizm. 8. Czynniki wirulencji C. pseudotuberculosis. 8.1. Lipidy powierzchniowe. 8.2. Fosfolipaza D. 8.3. Inne czynniki chorobotwórczosci C. pseudotuberculosis. 9. Podsumowanie

Corynebacterium pseudotuberculosis - pathogenic processes in animals

Abstract: Corynebacterium pseudotuberculosis is a small Gram-positive rod-shaped bacterium belonging to the family of Corynebacteriaceae. This bacterium has been isolated from abscesses and other suppurative processes in a variety of animal species, including small ruminants, horses and cattle. The disease caused by C. pseudotuberculosis is prevalent in many parts of the world and represents a serious problem for the sheep and goat industries. Infection of human beings is quite rare. Significant variability in biochemical properties of C. pseudotuberculosis has been reported. There are two distinct biotypes of C. pseudotuberculosis - the first of ovine origin and the second of equine origin. The differentiation between biotypes is based mainly on their ability to reduce nitrate.
The pathogenesis of infection is not well defined, but many investigations have shown that two virulence factors of C. pseudotuberculosis play essential roles in the development of the disease. One of these is the cell wall surface lipid which allows the bacteria to resist digestion by phagocytes and so persist as a facultative intracellular parasite. The second important component of the pathogenicity of C. pseudotuberculosis is an exotoxin, phospholipase D, which is thought to mediate dissemination of the pathogen within the host by increasing local vascular permeability.
Among materials concerning this subject in the Polish language there are a few publications describing mainly the characteristics of the illness but not the bacterium itself. The present review focuses on the changes in nomenclature and taxonomy of C. pseudotuberculosis, phenotypic characterization of the bacterium, its occurrence and pathogenicity. The mechanism of pathogenesis and the major virulence factors of C. pseudotuberculosis are also described.

1. Introduction. 2. Cell wall of Corynebacterium sp. 3. Properties of C. pseudotuberculosis. 4. Biotypes of C. pseudotuberculosis. 5. Occurence. 6. Pathogenicity. 7. Pathogenesis. 8. Virulence factors of C. pseudotuberculosis. 8.1. Cell wall surface lipid. 8.2. Phospholipase D. 8.3. Others virulence factors of C. pseudotuberculosis. 9. Summary

Słowa kluczowe: chorobotworczość, Corynebacterium pseudotuberculosis,
                            czynniki wirulencji, fosfolipaza D, serowaciejące zapalenie
                             węzłów chłonnych
Key words: pathogenicity, Corynebacterium pseudotuberculosis, virulence
                   factors, phospholipase D, caseous lymphadenitis

 


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