CZY CHLAMYDOPHILA PNEUMONIAE
MOŻE BYĆ CZYNNIKIEM ETIOLOGICZNYM
CHORÓB NIEINFEKCYJNYCH?
Edyta Podsiadły, Stanisława Tylewska-Wierzbanowska
Samodzielna Pracownia Riketsji, Chlamydii i Krętków Odzwierzęcych, Państwowy Zakład Higieny
ul. Chocimska 24, 00-791 Warszawa, e-mail: epodsiadly@pzh.gov.pl
Wpłynęło w kwietniu 2004 r.
1. Wstęp. 2. Zakażenia układu oddechowego. 2.1. Astma
oskrzelowa. 2.2. Rak płuc. 2.3. Przewlekła obturacyjna choroba płuc. 3. Odczynowe zapalenie stawów. 4. Choroby układu
nerwowego. 4.1. Stwardnienie rozsiane. 4.2. Choroba
Alzheimera. 5. Miażdżyca. 5.1. Badania kliniczne. 5.2. Badania doświadczalne. 5.2.1. Modele zwierzęce. 5.2.2. Mechanizm. 5.2.3. Próby leczenia choroby wieńcowej
antybiotykami. 6. Podsumowanie
Is Chlamydophila pneumoniae an etiological agent of non-infectious diseases? Abstract:
Chlamydia pneumoniae is an obligate, intracellular pathogen. It is a common cause of human respiratory diseases, responsible for 10% of community-acquired pneumonia and 5% of bronchitis, pharyngitis and sinusitis. It is postulated that
C. pneumoniae might be associated with other acute and chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease and lung cancer. Chlamydial DNA and viable organisms have been found in cerebrospinal fluid of multiple sclerosis patients.
C. pneumoniae was also identificated and localized in brain of patients suffering from Alzheimerís disease. The role of
C. pneumoniae in Alzheimerís disease and multiple sclerosis is not well defined.
C. pneumoniae may also trigger reactive arthritis. It has been demonstrated that
C. pneumoniae DNA is present in synovial tissue of some patients with reactive arthritis. The bacteria are viable
in synovium, and probably occur in persistent state of aberrant bodies and aberrant inclusions. The expanding spectrum of
C. pneumoniae infection sequels has been extended to atherosclerosis and related clinical manifestation such as coronary heart disease. Demonstration of the bacteria in atherosclerotic tissue and higher prevalence of specific
C. pneumoniae serum antibodies in persons with coronary heart disease then in healthy subjects support the hypothesis. Animal model studies have confirmed the role
of C. pneumoniae infection in the atherosclerotic process. Further investigations are required to confirm or to exclude the hypothesis on the association of C. pneumoniae with diseases regarded so far as non-infectious. Standardization and improvement of microbiologic methods used in studies of C. pneumoniae are necessary to get final confirmation
1. Introduction. 2. Respiratory tract infections. 2.1. Bronchial asthma. 2.2. Lung cancer. 2.3. Chronic obstructive pulmonary disease
(COPD). 3. Reactive arthritis. 4. Neurological diseases. 4.1. Multiple sclerosis. 4.2. Alzheimerís disease. 5. Atherosclerosis. 5.1. Clinical studies. 5.2. Experimental studies. 5.2.1. Animal models. 5.2.2. Mechanism. 5.2.3. Antibiotic treatment trials of coronary heart disease. 6. Final remarks
Słowa kluczowe: Chlamydophila pneumoniae, choroba Alzheimera, miażdżyca, stwardnienie rozsiane, astma
Keywords: Chlamydophila pneumoniae, Alzheimerís disease, atherosclerosis, multiple sclerosis, asthma
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