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ROLA FIMBRII SPIRALNYCH (FS)
W CHOROBOTWÓRCZOŚCI ESCHERICHIA COLI
Beata Magdalena Sobieszczańska
Katedra i Zakład Mikrobiologii Akademii Medycznej, ul. Chałubińskiego 4, 50-368 Wrocław
tel. (071) 784 12 78, e-mail mapasobie@provider.pl
Wpłynęło w lipcu 2004
1. Wstęp 2. Fimbrie spiralne FS. 3. Genetyczna regulacja syntezy FS. 4. Cechy biologiczne FS. 5. Wpływ ekspresji fimbrii FS na chorobotworczość
E. coli. 6. Podsumowanie
The role of curli fimbria in the pathogenesis of
Escherichia coli infections
Abstract: Curli fimbria are thin surface fibers that shows unusual property of several human plasmatic and cell matrix proteins binding e.g. laminin, fibronectin, plasminogen, fibrinogen MHC class I molecules. Fibrinogen plays an important role in homeostasis and activation of the coagulation cascade at the bacteria surface may contribute to the pathogenesis of
E. coli sepsis. Curli are expressed by many pathogenic as well as wild and laboratory
E. coli strains. Their expression is controlled by environmental and genetic factors. Most of
E. coli strains are producing these structures at low temperatures during starvation making them responsible for biofilm formation on abiotic surfaces. Although the role of curli in sepsis development has been proven on animals, there are a lot of aspects of clinical importance of curli for further investigation.
1. Introduction. 2. Curli fimbria. 3. Genetic regulation of curli production. 4. Biological properties of curli. 5. The influence of curli expression on pathogenicity of
E. coli. 6. Summary
Słowa
kluczowe: biofilm, fimbrie spiralne FS, E. coli,
fimbrie, posocznica
Key words: biofilm, curli, E. coli,
fimbria, sepsis |
