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STRUKTURA
WIRUSA NIEDOBORU
ODPORNOŚĆ
BYDŁA
I
CHARAKTERYSTYKA
NATURALNYCH
ZAKAŻEŃ
Marzena Rola, Jacek Kuźmak
l. Wstęp.
2. Molekularna charakterystyka wirusa. 2.1. Struktura
wirionu. 2.2. Genom i białka wirusa. 3. Cykl
replikacyjny. 4. Zmienność genetyczna. 5. Powinowactwo
komórkowe i wrażliwość zwierząt. 6. Patogenne
działanie. 7. Podsumowanie
Structure
and pathogenesis of bovine immunodeficiency virus (BIV)
Abstract:
The
Bovine Immunodeficiency Virus (BIV) is a lentiviral pathogen
causes a latent viral infection
of cattle and appears to be widespread in the cattle population in the world. A subsequent study has shown that BIV is
genetically similar to human immunodeficiency virus (HIV). Like
other lentiviruses BIV is characterized
by high genetic diversity and env gene seems to be the most affected
by genetic variation. Evaluation of the cell tropism of BIV
revealed that the virus may be pantropic
for leukocytes. The pathologic effect on cattle has not been
determined, although some reports have linked BIV to clinical
immunodeficiency, lymphoadenopathy and lymphoproliferation. It
is presumable that BlV-induced immune dysfunction can predispose
cattle to infection with other pathogens,
although little is known about the effects and consequences of
mixed infections of BIV and other infectious agents.
1. Introduction.
2. Molecular characterization of BIV. 2.1. Properties of
the virion. 2.2. Properties of the genome.
3. Replication cycle. 4. Genetic variability. 5. Host
range and tissue tropism. 6. Pathogenesis.
7. Summary
Zakład
Biochemii, Państwowy Instytut Weterynaryjny
Al. Partyzantów 57, 24-100 Puławy
Wpłynęło
w lutym 2004 r. |
