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MUTAGENNE
I KARCYNOGENNE
METABOLITY TWORZONE
PRZEZ
MIKROFLORĘ
JELITA
GRUBEGO CZŁOWIEKA
Adriana
Nowak, Zdzisława Libudzisz
1. Jelitowa
flora bakteryjna zdrowego człowieka. 2. Znaczenie i funkcje
mikroflory jelitowej. 3. Karcynogenne
metabolity w jelicie grubym człowieka. 3.1. Aglikony
flawonoidowe. 3.2. Indole, fenole,
krezole i skatole. 3.3. N-nitrozozwiązki (NOC). 3.4. Heterocykliczne
aminy aromatyczne (HCA). 3.5. Fekapentaeny (FP). 3.6. Drugorzędowe
kwasy żółciowe. 3.7. Barwniki azowe. 4. Anty-mutagenne
i antykarcynogenne działanie bakterii fermentacji mlekowej. 5. Podsumowanie
Mutagenic
and carcinogenic metabolites formed by human clonic flora
Abstract: The human colon is host to a
diverse range of bacteria with number of species reaching 400-500.
This population plays a significant role in intestinal metabolism
of dietary substrates and in human
health. Some of products of this metabolism are associated with mutagenesis
and carcinogenesis of
the colon. There are several bacterial anzymes involved in
carcinogens formation including: b-glucuronidase, b-glucosidase, b-galactosidase, urease, azoreduktaze and nitroreduktaze. These enzymes
are engaged in dietary metabolism in the gut releasing toxic
metabolites such as: phenol, indols, aromatic, amines, cresols,
flavonoid aglycones, N-nitroso compounds and secondary bile acids. Probiotics are alive cultures of lactic acid bacteria which have a
range of healthful effects for human. Although there are strong
indications that probiotics may posses cancer preventive
proper-ties, the strict mechanism of their action is still unknown
1. Normal
gut flora of healthy human. 2. Significance and function of
intestinal microflora. 3. Carcinogenic
metabolites in human colon. 3.1. Flavonoid aglycones. 3.2. Indols,
phenols, cresols and skatoles. 3.3. N-nitroso
compounds (NOC). 3.4. Heterocyclic aromatic amines (HCA).
3.5. Fekapentaenes. 3.6. Secondary
bile acids. 3.7. Azo dyes. 4. Antimutagenic properties
of lactic acid bacteria. 5. Summary
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